Abstract Cancer stem-like cells (CSC) contribute to therapy resistance and recurrence.Focal adhesion kinase (FAK) has a role in CSC regulation.We determined the effect of FAK inhibition on breast CSC activity Crafting Books alone and in combination with adjuvant therapies.FAK inhibition reduced CSC activity and self-renewal across all molecular sub
The basic pharmacokinetic parameters of MTX administered as monotherapy as well as in the combined therapy with simultaneous and prior administation of FU were investigated.The parameters were determined in the two-compartment open system on the basis of measurement of MTX levels in mice after i.p.administration of a single dose 20 mg/ kg of the dr
The impacts of natural hazards as well as their frequency of occurrence during the Program Sticker last decades have increased decisively.Therefore, the public as well as the private sector are expected to react to this development by providing sufficient funds, in particular for the improvement of protection measures and an enhanced funding of dam
A 69-year-old lady diagnosed with congestive cardiac failure three years prior presented with worsening shortness of breath and bilateral leg swelling.She does not have a history of acute coronary syndrome, however an angiogram performed two years ago revealed a two-vessel disease.She also has hypothyroidism secondary to thyroidectomy.A cardiovascu